Tetraploidy-Associated Genetic Heterogeneity Confers Chemo-Radiotherapy Resistance to Colorectal Cancer Cells

Tetraploidy-Associated Genetic Heterogeneity Confers Chemo-Radiotherapy Resistance to Colorectal Cancer Cells

Tetraploidy, or whole-genome duplication, is a common phenomenon in cancer and preludes chromosome instability, which strongly correlates with disease progression, metastasis, and treatment failure. Therefore, it is reasonable to hypothesize that tetraploidization confers multidrug resistance. Never...

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Bibliographic Details
Main Authors: Claudia Galofré, Öykü Gönül Geyik, Elena Asensio, Darawalee Wangsa, Daniela Hirsch, Carolina Parra, Jordi Saez, Meritxell Mollà, Zeynep Yüce, Antoni Castells, Thomas Ried, Jordi Camps
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
tetraploidy
whole-genome duplication
chemotherapy
radiotherapy
drug resistance
colorectal cancer
Online Access:https://www.mdpi.com/2072-6694/12/5/1118

Internet

https://www.mdpi.com/2072-6694/12/5/1118

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