Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea

Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea

Hair cell (HC) loss is irreversible because only very limited HC regeneration has been observed in the adult mammalian cochlea. Wnt/β-catenin signaling regulates prosensory cell proliferation and differentiation during cochlear development, and Wnt activation promotes the proliferation of Lgr5+ coch...

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Bibliographic Details
Main Authors: Yanping Zhang, Luo Guo, Xiaoling Lu, Cheng Cheng, Shan Sun, Wen Li, Liping Zhao, Chuijin Lai, Shasha Zhang, Chenjie Yu, Mingliang Tang, Yan Chen, Renjie Chai, Huawei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Wnt
Lgr5
Lgr6
proliferation
differentiation
hair cell
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00147/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00147/full

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