Neuropilin-1 drives tumor-specific uptake of chlorotoxin

Neuropilin-1 drives tumor-specific uptake of chlorotoxin

Abstract Background Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies, and the imaging agent tozuleristide, is under investigation in CNS...

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Bibliographic Details
Main Authors: Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe, Kenichi Nomoto
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cell Communication and Signaling
Subjects:
Chlorotoxin
Neuropilin-1
Tumor
Uptake
Peptide-drug-conjugate
Online Access:http://link.springer.com/article/10.1186/s12964-019-0368-9

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http://link.springer.com/article/10.1186/s12964-019-0368-9

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