Cytolethal Distending Toxin Enhances Radiosensitivity in Prostate Cancer Cells by Regulating Autophagy

Cytolethal Distending Toxin Enhances Radiosensitivity in Prostate Cancer Cells by Regulating Autophagy

Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and, consequently, cell cycle arrest at the G2/M stag...

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Bibliographic Details
Main Authors: Hwai-Jeng Lin, Hsin-Ho Liu, Chia-Der Lin, Min-Chuan Kao, Yu-An Chen, Chuan Chiang-Ni, Zhi-Pei Jiang, Mei-Zi Huang, Chun-Jung Lin, U-Ging Lo, Li-Chiung Lin, Cheng-Kuo Lai, Ho Lin, Jer-Tsong Hsieh, Cheng-Hsun Chiu, Chih-Ho Lai
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Campylobacter jejuni
cytolethal distending toxin
cell cycle
autophagy
radioresistance
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00223/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00223/full

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