Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction
SUMMARY Cardiac fibrosis is critically involved in the adverse remodeling accompanying dilated cardiomyopathies (DCMs), which leads to cardiac dysfunction and heart failure (HF). Connective tissue growth factor (CTGF), a profibrotic cytokine, plays a key role in this deleterious process. Some benefi...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2012-07-01
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Series: | Disease Models & Mechanisms |
Online Access: | http://dmm.biologists.org/content/5/4/481 |