Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses

Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses

Synthesis of extracellular adenosine by the ectonucleotidases CD39 and CD73 represents an important pathway of immune suppression in the tumor microenvironment. Using two mouse models (RET transgenic melanoma and Panc02 orthotopic pancreatic adenocarcinoma), we identified an elevated frequency of ec...

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Bibliographic Details
Main Authors: Ivan Shevchenko, Andreas Mathes, Christopher Groth, Svetlana Karakhanova, Verena Müller, Jochen Utikal, Jens Werner, Alexandr V. Bazhin, Viktor Umansky
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
melanoma
pancreatic adenocarcinoma
ectonucleotidases
adenosine
effector t cells
immunosuppression
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1744946

Internet

http://dx.doi.org/10.1080/2162402X.2020.1744946

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