Sorghum polyphenol suppresses the growth as well as metastasis of colon cancer xenografts through co-targeting jak2/STAT3 and PI3K/Akt/mTOR pathways

Sorghum polyphenol suppresses the growth as well as metastasis of colon cancer xenografts through co-targeting jak2/STAT3 and PI3K/Akt/mTOR pathways

Sorghum contains phytochemicals that can protect against multiple forms of cancers. However, the underlying molecular targets and cellular mechanisms remain unknown. We investigated the role of Hwanggeumchal sorghum extracts (HSE) on colon cancer cells. We found HSE inhibited the proliferation of hu...

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Bibliographic Details
Main Authors: Pramod Darvin, Youn Hee Joung, Nipin S P, Dong Young Kang, Hyo Joo Byun, Dae Yong Hwang, Kwang Hyun Cho, Kyung Do Park, Hak Kyo Lee, Young Mok Yang
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Journal of Functional Foods
Subjects:
Hwanggeumchal sorghum
Jak2/STAT3
PI3K/Akt/mTOR
Colon cancer xenografts
Pulmonary metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615001280

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http://www.sciencedirect.com/science/article/pii/S1756464615001280

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