LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice[S]

LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice[S]

To investigate the role of liver X receptor (LXR) in adipose tissue metabolism during obesity, ob/ob mice were treated for 5 weeks with the synthetic LXR agonist GW3965. MRI analysis revealed that pharmacological activation of LXR modified fat distribution by decreasing visceral (VS) fat and inverse...

Full description

Bibliographic Details
Main Authors: Amena Archer, Émilie Stolarczyk, Maria Luisa Doria, Luisa Helguero, Rosário Domingues, Jane K. Howard, Agneta Mode, Marion Korach-André, Jan-Åke Gustafsson
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Journal of Lipid Research
Subjects:
liver X receptor
lipidomic analysis
immune cell infiltration
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520421686

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520421686

Similar Items