EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease

EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease

Abstract Background EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. These processes are pivotal in the pathophysiology of Alzheimer’s disease (AD), characterized by synapse dysfunction and loss, and the progressive loss of memory and other cognitive...

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Bibliographic Details
Main Authors: Lindsay Poppe, Laura Rué, Mieke Timmers, Annette Lenaerts, Annet Storm, Zsuzsanna Callaerts-Vegh, Gilles Courtand, Antina de Boer, Silke Smolders, Philip Van Damme, Ludo Van Den Bosch, Rudi D’Hooge, Bart De Strooper, Wim Robberecht, Robin Lemmens
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Alzheimer’s Research & Therapy
Subjects:
EphA4
Ephrins
Alzheimer’s disease
Dendritic spine
Synapse
Social memory
Online Access:https://doi.org/10.1186/s13195-019-0554-4

Internet

https://doi.org/10.1186/s13195-019-0554-4

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