Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy

Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy

Abstract Background Human CUB and Sushi multiple domains 1 (CSMD1) is a large membrane-bound tumor suppressor in breast cancer. The current study aimed to elucidate the molecular mechanism underlying the effect of CSMD1 in highly invasive triple negative breast cancer (TNBC). Methods We examined the...

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Bibliographic Details
Main Authors: Chrysostomi Gialeli, Emre Can Tuysuz, Johan Staaf, Safia Guleed, Veronika Paciorek, Matthias Mörgelin, Konstantinos S. Papadakos, Anna M. Blom
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
CSMD1
EGFR trafficking
Chemosensitivity
Breast cancer
Online Access:https://doi.org/10.1186/s13046-021-02042-1

Internet

https://doi.org/10.1186/s13046-021-02042-1

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