Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance

Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance

Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) are associated with parasite resistance to the imidazolopiperazines, a potent class of novel antimalarial compounds that display both prophylactic and transmission-blocking activity, in addition to activity against blood-s...

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Bibliographic Details
Main Authors: Gregory LaMonte, Michelle Yi-Xiu Lim, Melanie Wree, Christin Reimer, Marie Nachon, Victoria Corey, Peter Gedeck, David Plouffe, Alan Du, Nelissa Figueroa, Bryan Yeung, Pablo Bifani, Elizabeth A. Winzeler
Format: Article
Language:English
Published: American Society for Microbiology 2016-07-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/4/e00696-16

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http://mbio.asm.org/cgi/content/full/7/4/e00696-16

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