HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for “Off-the-Shelf” Immunotherapy

HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for “Off-the-Shelf” Immunotherapy

Cellular immunotherapy using chimeric antigen receptors (CARs) so far has almost exclusively used autologous peripheral blood-derived T cells as immune effector cells. However, harvesting sufficient numbers of T cells is often challenging in heavily pre-treated patients with malignancies and perturb...

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Bibliographic Details
Main Authors: Keven Hoerster, Markus Uhrberg, Constanze Wiek, Peter A. Horn, Helmut Hanenberg, Stefan Heinrichs
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
NK cells
B2M knockout
HLA class I
off-the-shelf
allogeneic
genome editing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.586168/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.586168/full

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