Zika Virus Inhibits IFN-α Response by Human Plasmacytoid Dendritic Cells and Induces NS1-Dependent Triggering of CD303 (BDCA-2) Signaling

Zika Virus Inhibits IFN-α Response by Human Plasmacytoid Dendritic Cells and Induces NS1-Dependent Triggering of CD303 (BDCA-2) Signaling

Zika virus (ZIKV) dramatically emerged in French Polynesia and subsequently in the Americas where it has been associated with severe neurological complications in adults and newborns, respectively. Although plasmacytoid dendritic cells (pDCs) are a key sensor of viral infection and are critical for...

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Bibliographic Details
Main Authors: Sandra Bos, Béatrice Poirier-Beaudouin, Valérie Seffer, Maria Manich, Cartini Mardi, Philippe Desprès, Gilles Gadea, Marie-Lise Gougeon
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
Zika virus (ZIKV)
plasmacytoid dendritic cells (pDC)
IFN—interferon
CD303
non-structural protein 1 (NS1)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.582061/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.582061/full

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