Pharmacological Activation of Estrogen Receptor Beta Overcomes Tumor Resistance to Immune Checkpoint Blockade Therapy

Pharmacological Activation of Estrogen Receptor Beta Overcomes Tumor Resistance to Immune Checkpoint Blockade Therapy

Summary: The emerging immune checkpoint blockade (ICB) therapy has ushered the cancer therapeutics field into an era of immunotherapy. Although ICB treatment provides remarkable clinical responses in a subset of patients with cancer, this regimen fails to extend survival in a large proportion of pat...

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Bibliographic Details
Main Authors: Shuang Huang, Nianxin Zhou, Linjie Zhao, Ryan C. Gimple, Young Ha Ahn, Peidong Zhang, Wei Wang, Bin Shao, Jingyun Yang, Qian Zhang, Sai Zhao, Xuehan Jiang, Zhiwei Chen, Yangfan Zeng, Hongbo Hu, Jan-Åke Gustafsson, Shengtao Zhou
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Immunology
Endocrine Treatment
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306507

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220306507

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