Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring

Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring

Abstract Background Pediatric leukemias have a diverse genomic landscape associated with complex structural variants, including gene fusions, insertions and deletions, and single nucleotide variants. Routine karyotype and fluorescence in situ hybridization (FISH) techniques lack sensitivity for smal...

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Bibliographic Details
Main Authors: Erin L. Crowgey, Nitin Mahajan, Wing Hing Wong, Anilkumar Gopalakrishnapillai, Sonali P. Barwe, E. Anders Kolb, Todd E. Druley
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Medical Genomics
Subjects:
Error-corrected sequencing
Minimal residual disease
Next generation sequencing
Pediatric leukemia
Computational biology
Online Access:http://link.springer.com/article/10.1186/s12920-020-0671-8

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http://link.springer.com/article/10.1186/s12920-020-0671-8

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