Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides

Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. New effective Tdp1 inhibitors were found in a series of nucleoside derivatives possessing 2′,3′,5′-tri-<i>O</i>-...

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Bibliographic Details
Main Authors: Alexandra L. Zakharenko, Mikhail S. Drenichev, Nadezhda S. Dyrkheeva, Georgy A. Ivanov, Vladimir E. Oslovsky, Ekaterina S. Ilina, Irina A. Chernyshova, Olga I. Lavrik, Sergey N. Mikhailov
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
nucleosides
DNA repair
tyrosyl-DNA phosphodiesterase
Tdp1 inhibition
topotecan
Online Access:https://www.mdpi.com/1420-3049/25/16/3694

Internet

https://www.mdpi.com/1420-3049/25/16/3694

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