Mitochondrial oxidative stress causes hyperphosphorylation of tau.

Mitochondrial oxidative stress causes hyperphosphorylation of tau.

Age-related neurodegenerative disease has been mechanistically linked with mitochondrial dysfunction via damage from reactive oxygen species produced within the cell. We determined whether increased mitochondrial oxidative stress could modulate or regulate two of the key neurochemical hallmarks of A...

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Bibliographic Details
Main Authors: Simon Melov, Paul A Adlard, Karl Morten, Felicity Johnson, Tamara R Golden, Doug Hinerfeld, Birgit Schilling, Christine Mavros, Colin L Masters, Irene Volitakis, Qiao-Xin Li, Katrina Laughton, Alan Hubbard, Robert A Cherny, Brad Gibson, Ashley I Bush
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1888726?pdf=render

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http://europepmc.org/articles/PMC1888726?pdf=render

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