Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

The heterogeneity of tumor evolution from AR-positive, adenocarcinoma to AR-negative, neuroendocrine prostate cancer (NEPC) is not fully characterized. Here the authors generate a mouse model to show that Rb1 loss and MYCN overexpression accelerates the progression to AR-negative NEPC and identify e...

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Bibliographic Details
Main Authors: Nicholas J. Brady, Alyssa M. Bagadion, Richa Singh, Vincenza Conteduca, Lucie Van Emmenis, Elisa Arceci, Hubert Pakula, Ryan Carelli, Francesca Khani, Martin Bakht, Michael Sigouros, Rohan Bareja, Andrea Sboner, Olivier Elemento, Scott Tagawa, David M. Nanus, Massimo Loda, Himisha Beltran, Brian Robinson, David S. Rickman
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23780-y

Internet

https://doi.org/10.1038/s41467-021-23780-y

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