Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption[S]

Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption[S]

Monoacylglycerol lipase (MGL) is the rate-limiting enzyme in the degradation of monoacylglycerols. To examine the role of MGL in hepatic steatosis, WT and MGL KO (MGL−/−) mice were challenged with a Western diet (WD) over 12 weeks. Lipid metabolism, inflammation, and fibrosis were assessed by serum...

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Bibliographic Details
Main Authors: Matteo Tardelli, Francesca V. Bruschi, Thierry Claudel, Claudia D. Fuchs, Nicole Auer, Victoria Kunczer, Tatjana Stojakovic, Hubert Scharnagl, Aida Habib, Gernot F. Grabner, Robert Zimmermann, Sophie Lotersztajn, Michael Trauner
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Journal of Lipid Research
Subjects:
nonalcoholic fatty liver disease
monoacylglycerol lipase
obesity
lipolysis and fatty acid metabolism
nuclear receptors/peroxisome proliferator-activated receptor
adipocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520310609

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http://www.sciencedirect.com/science/article/pii/S0022227520310609

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