Autophagic Degradation Deficit Involved in Sevoflurane-Induced Amyloid Pathology and Spatial Learning Impairment in APP/PS1 Transgenic Mice

Autophagic Degradation Deficit Involved in Sevoflurane-Induced Amyloid Pathology and Spatial Learning Impairment in APP/PS1 Transgenic Mice

The adverse effects of anesthetics on elderly people, especially those with brain diseases are very concerning. Whether inhaled anesthetics have adverse effects on Alzheimer’s disease (AD), which is the most common form of dementia with brain degenerative changes, remains controversial. Autophagy, a...

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Bibliographic Details
Main Authors: Pengcheng Geng, Jiqian Zhang, Wei Dai, Xiaoyu Han, Qilian Tan, Dan Cheng, Panpan Fang, Xuesheng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
cognitive dysfunctions
sevoflurane
autophagic degradation
enlarged autolysosomes
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00185/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00185/full

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