Liposomes Loaded With Phosphatidylinositol 5-Phosphate Improve the Antimicrobial Response to Pseudomonas aeruginosa in Impaired Macrophages From Cystic Fibrosis Patients and Limit Airway Inflammatory Response

Liposomes Loaded With Phosphatidylinositol 5-Phosphate Improve the Antimicrobial Response to Pseudomonas aeruginosa in Impaired Macrophages From Cystic Fibrosis Patients and Limit Airway Inflammatory Response

Despite intensive antimicrobial and anti-inflammatory therapies, cystic fibrosis (CF) patients are subjected to chronic infections due to opportunistic pathogens, including multidrug resistant (MDR) Pseudomonas aeruginosa. Macrophages from CF patients show many evidences of reduced phagocytosis in t...

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Bibliographic Details
Main Authors: Noemi Poerio, Federica De Santis, Alice Rossi, Serena Ranucci, Ida De Fino, Ana Henriquez, Marco M. D’Andrea, Fabiana Ciciriello, Vincenzina Lucidi, Roberto Nisini, Alessandra Bragonzi, Maurizio Fraziano
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
phosphatidylinositol 5-phospate
host-directed therapy
cystic fibrosis
innate immunity
Pseudomonas aeruginosa
liposome
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.532225/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.532225/full

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