Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer’s Disease

Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer’s Disease

Circulating neuronal extracellular vesicles (NEVs) of Alzheimer’s disease (AD) patients show high Tau and β-amyloid (Aβ) levels, whereas their astrocytic EVs (AEVs) contain high complement levels. To validate EV proteins as AD biomarkers, we immunocaptured NEVs and AEVs from plasma collected from fi...

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Bibliographic Details
Main Authors: Francheska Delgado-Peraza, Carlos J. Nogueras-Ortiz, Olga Volpert, Dong Liu, Edward J. Goetzl, Mark P. Mattson, Nigel H. Greig, Erez Eitan, Dimitrios Kapogiannis
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
extracellular vesicles
exosomes
Alzheimer’s
transgenic
biomarkers
Tau
Online Access:https://www.mdpi.com/2073-4409/10/5/993

Internet

https://www.mdpi.com/2073-4409/10/5/993

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