Allele-Specific MicroRNA-Mediated Regulation of a Glycolysis Gatekeeper PDK1 in Cancer Metabolism

Allele-Specific MicroRNA-Mediated Regulation of a Glycolysis Gatekeeper PDK1 in Cancer Metabolism

Background: Emerging evidence has revealed that genetic variations in microRNA (miRNA) binding sites called miRSNPs can alter miRNA binding in an allele-specific manner and impart prostate cancer (PCa) risk. Two miRSNPs, rs1530865 (G > C) and rs2357637 (C > A), in the 3′ untranslated region of...

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Bibliographic Details
Main Authors: Sugarniya Subramaniam, Varinder Jeet, Jennifer H. Gunter, Judith A. Clements, Jyotsna Batra
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
PDK1
metabolic reprogramming
single-nucleotide polymorphisms
microRNAs
Online Access:https://www.mdpi.com/2072-6694/13/14/3582

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https://www.mdpi.com/2072-6694/13/14/3582

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