Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

Abstract Background Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia. This is caused by a d...

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Bibliographic Details
Main Authors: Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters, Torben Hansen
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Genetics
Subjects:
hERG ion channel
QT interval
KCHN2
Glucagon
Glucose-dependent insulinotropic polypeptide (GIP)
Glucagon-like peptide-1 (GLP-1)
Online Access:http://link.springer.com/article/10.1186/s12863-018-0602-2

Internet

http://link.springer.com/article/10.1186/s12863-018-0602-2

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