L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution

L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution

Summary: LINE-1 (L1) retrotransposons are a source of insertional mutagenesis in tumor cells. However, the clinical significance of L1 mobilization during tumorigenesis remains unclear. Here, we applied retrotransposon capture sequencing (RC-seq) to multiple single-cell clones isolated from five ova...

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Main Authors: Thu H.M. Nguyen, Patricia E. Carreira, Francisco J. Sanchez-Luque, Stephanie N. Schauer, Allister C. Fagg, Sandra R. Richardson, Claire M. Davies, J. Samuel Jesuadian, Marie-Jeanne H.C. Kempen, Robin-Lee Troskie, Cini James, Elizabeth A. Beaven, Tristan P. Wallis, Jermaine I.G. Coward, Naven P. Chetty, Alexander J. Crandon, Deon J. Venter, Jane E. Armes, Lewis C. Perrin, John D. Hooper, Adam D. Ewing, Kyle R. Upton, Geoffrey J. Faulkner
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718308714

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http://www.sciencedirect.com/science/article/pii/S2211124718308714

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