Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation

Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation

Parkinson’s disease is a neurodegenerative disorder in which activated microglia may appear prior to motor symptoms, but the specific therapeutic mechanisms remain unclear. This study investigated the potential effects of Edaravone (EDA) on M1/M2 polarization of microglia in rats with dopaminergic n...

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Bibliographic Details
Main Authors: Jiping Li, Xinping Dai, Liuyi zhou, Xinxiu Li, Dongxiao Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
parkinson’s disease
microglia
inflammasome
edaravone
polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.691773/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.691773/full

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