GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization

GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization

Abstract Background Influenza A viruses cause life-threatening pneumonia and lung injury in the lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown to reduce morbidity and mortality from pathogenic influenza infection in mice, but the mechanisms of protection...

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Bibliographic Details
Main Authors: E. Scott Halstead, Todd M. Umstead, Michael L. Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Kurundu Hewage, Zissis C. Chroneos
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Respiratory Research
Subjects:
Influenza
GM-CSF
Macrophage
Alveolar
Exudative
Pneumonia
Online Access:http://link.springer.com/article/10.1186/s12931-017-0708-5

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http://link.springer.com/article/10.1186/s12931-017-0708-5

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