Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA.

Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA.

Developing a vaccine that overcomes the diversity of HIV-1 is likely to require a strategy that directs antibody (Ab) responses toward conserved regions of the viral Envelope (Env). However, the generation of neutralizing Abs (NAbs) targeting these regions through vaccination has proven to be diffic...

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Bibliographic Details
Main Authors: Shelly J Krebs, Sean P McBurney, Dina N Kovarik, Chelsea D Waddell, J Pablo Jaworski, William F Sutton, Michelle M Gomes, Maria Trovato, Garret Waagmeester, Susan J Barnett, Piergiuseppe DeBerardinis, Nancy L Haigwood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4267727?pdf=render

Internet

http://europepmc.org/articles/PMC4267727?pdf=render

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