Transfer of MicroRNA-216a-5p From Exosomes Secreted by Human Urine-Derived Stem Cells Reduces Renal Ischemia/Reperfusion Injury

Transfer of MicroRNA-216a-5p From Exosomes Secreted by Human Urine-Derived Stem Cells Reduces Renal Ischemia/Reperfusion Injury

Human urine-derived stem cells (USCs) protect rats against kidney ischemia/reperfusion (I/R) injury. Here we investigated the role of USCs exosomes (USCs-Exos) in protecting tubular endothelial cells and miRNA transfer in the kidney. Human USCs and USCs-Exos were isolated and verified by morphology...

Full description

Bibliographic Details
Main Authors: Yinmei Zhang, Junxiong Wang, Boxin Yang, Rui Qiao, Aiwei Li, Han Guo, Jie Ding, Hui Li, Hong Ye, Di Wu, Liyan Cui, Shuo Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
acute kidney injury
human urine-derived stem cells
exosomes
miR-216a-5p
phosphatase and tensin homolog
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.610587/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.610587/full

Similar Items