Mechanisms underlying the promotion of functional recovery by deferoxamine after spinal cord injury in rats

Mechanisms underlying the promotion of functional recovery by deferoxamine after spinal cord injury in rats

Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in a rat model of spinal cord injury and explored potential mechanisms for this effec...

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Bibliographic Details
Main Authors: Jian Hao, Bo Li, Hui-quan Duan, Chen-xi Zhao, Yan Zhang, Chao Sun, Bin Pan, Chang Liu, Xiao-hong Kong, Xue Yao, Shi-qing Feng
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; spinal cord injury; deferoxamine; tumor necrosis factor-α; interleukin-1β; apoptosis; iron; anti-inflammatory; glial scar; proinflammatory; rats; motor function; lipid peroxidation; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=6;spage=959;epage=968;aulast=Hao

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=6;spage=959;epage=968;aulast=Hao

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