Serum programmed cell death proteins in amyotrophic lateral sclerosis

Serum programmed cell death proteins in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem pro-inflammatory neuromuscular disorder. Activation of programmed cell death-1 (PD-1), and its ligands, programmed cell death-ligand 1 and 2 (PD-L1/L2), leads to immune suppression. Serum soluble forms of these proteins, sPD-1/sPD-...

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Bibliographic Details
Main Authors: David R. Beers, Weihua Zhao, Jason R. Thonhoff, Alireza Faridar, Aaron D. Thome, Shixiang Wen, Jinghong Wang, Stanley H. Appel
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Amyotrophic lateral sclerosis
Neuromuscular disease
Neurodegeneration
Program cell death proteins
Inflammation
Immune regulatory checkpoint pathways
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354621000120

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http://www.sciencedirect.com/science/article/pii/S2666354621000120

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