Refinement of the CS6-expressing enterotoxigenic Escherichia coli strain B7A human challenge model: A randomized trial.

Refinement of the CS6-expressing enterotoxigenic Escherichia coli strain B7A human challenge model: A randomized trial.

<h4>Background</h4>Human challenge models for enterotoxigenic Escherichia coli (ETEC) facilitate vaccine down-selection. The B7A (O148:H28 CS6+LT+ST+) strain is important for vaccine development. We sought to refine the B7A model by identifying a dose and fasting regimen consistently ind...

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Bibliographic Details
Main Authors: Kawsar R Talaat, Chad K Porter, Kayla M Jaep, Christopher A Duplessis, Ramiro L Gutierrez, Milton Maciel, Brittany Adjoodani, Brittany Feijoo, Subhra Chakraborty, Jessica Brubaker, Stefanie A Trop, Mark S Riddle, Sabrina S Joseph, A Louis Bourgeois, Michael G Prouty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0239888

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https://doi.org/10.1371/journal.pone.0239888

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