Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background
Thoracic aortic aneurysms (TAA) are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV) and aortopathy in humans. The aim of this study was to determ...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-03-01
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| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2308-3425/2/1/17 |