Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells

Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells

During blood-stage malaria, the innate immune system initiates the production of pro-inflammatory cytokines, including IFN-γ, that are critical to host defense and responsible for severe disease. Nonetheless, the innate immune pathways activated during this process in human malaria remain poorly und...

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Bibliographic Details
Main Authors: Christoph Coch, Benjamin Hommertgen, Thomas Zillinger, Juliane Daßler-Plenker, Bastian Putschli, Maximilian Nastaly, Beate M. Kümmerer, Johanna F. Scheunemann, Beatrix Schumak, Sabine Specht, Martin Schlee, Winfried Barchet, Achim Hoerauf, Eva Bartok, Gunther Hartmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
innate immune system
toll-like receptor 8
interleukin 12p70
interleukin 18
interferon gamma
NK cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00371/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00371/full

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