Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma

Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma

Current therapies for sarcomas are often inadequate. This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation. Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine,...

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Bibliographic Details
Main Authors: Simone Hettmer, Anna C Schinzel, Daria Tchessalova, Michaela Schneider, Christina L Parker, Roderick T Bronson, Nigel GJ Richards, William C Hahn, Amy J Wagers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
sarcoma
rhabdomyosarcoma
functional genomics
asparagine synthetase
asparaginase
Online Access:https://elifesciences.org/articles/09436

Internet

https://elifesciences.org/articles/09436

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