APECED: Is this a model for failure of T-cell and B-cell tolerance?
APECED and IPEX syndromes show similarities in the clinical presentations and immunological alterations, mainly regarding regulatory T-cells function. T-cell defect may lead to tissue destruction chiefly in endocrine organs. Besides, APECED is characterized by high-titer antibodies against a wide va...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00232/full |