Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide

Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide

Abstract Background 64Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development of stable chelators is essential to harness the potential of this isotope, challenged by the presence of endogenous copper ch...

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Bibliographic Details
Main Authors: Hua Yang, Feng Gao, Brooke McNeil, Chengcheng Zhang, Zheliang Yuan, Stefan Zeisler, Joel Kumlin, Jutta Zeisler, François Bénard, Caterina Ramogida, Paul Schaffer
Format: Article
Language:English
Published: SpringerOpen 2021-01-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Copper-64
Chelating ligands
Radiolabeling
α-Melanocyte-stimulating hormone
Pyridyl
DOTA
Online Access:https://doi.org/10.1186/s41181-020-00119-4

Internet

https://doi.org/10.1186/s41181-020-00119-4

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