Effect of Lowering Asymmetric Dimethylarginine (ADMA) on Vascular Pathology in Atherosclerotic ApoE-Deficient Mice with Reduced Renal Mass

Effect of Lowering Asymmetric Dimethylarginine (ADMA) on Vascular Pathology in Atherosclerotic ApoE-Deficient Mice with Reduced Renal Mass

The purpose of the work was to study the impact of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) and its degrading enzyme, dimethylarginine dimethylaminohydrolase (DDAH1), on atherosclerosis in subtotally nephrectomized (SNX) ApoE-deficient mice. Male DDAH1...

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Bibliographic Details
Main Authors: Johannes Jacobi, Renke Maas, Michaela Arend, Nada Cordasic, Karl F. Hilgers
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
ADMA
subtotal nephrectomy
atherosclerosis
Online Access:http://www.mdpi.com/1422-0067/15/4/5522

Internet

http://www.mdpi.com/1422-0067/15/4/5522

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