The A1 receptor agonist R-Pia reduces the imbalance between cerebral glucose metabolism and blood flow during status epilepticus: Could this mechanism be involved with neuroprotection?

The A1 receptor agonist R-Pia reduces the imbalance between cerebral glucose metabolism and blood flow during status epilepticus: Could this mechanism be involved with neuroprotection?

It is well known that the uncoupling between local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF), i.e. decrease in LCBF rates with high LCGU, is frequently associated with seizure-induced neuronal damage. This study was performed to assess if the neuroprotective effect of...

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Bibliographic Details
Main Authors: Iara Ribeiro Silva, Astrid Nehlig, Fernanda Elisa Rosim, Thiago Vignoli, Daniele Suzete Persike, Arielle Ferrandon, Rita Sinigaglia-Coimbra, Maria José da Silva Fernandes
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Neurobiology of Disease
Subjects:
Pilocarpine
Neuroprotection
Adenosine receptor
R-Pia, glucose metabolism
Cerebral blood flow
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003050

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110003050

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