Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells

Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells

Liver cancer is a critical clinical condition with augmented malignancy, rapid progression, and poor prognosis. Liver cancer often initiates as fibrosis, develops as cirrhosis, and results in cancer. For centuries, medicinal plants have been incorporated in various liver-associated complications, an...

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Bibliographic Details
Main Authors: Yulai You, Fengfeng Zhu, Zhenhuan Li, LingFeng Zhang, Yu Xie, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Bei Lu
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hepatocellular carcinoma
Phyllanthin
Diethylnitrosamine
HepG2 cell line
mTOR/PI3K signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221001207

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http://www.sciencedirect.com/science/article/pii/S0753332221001207

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