Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE

Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE

Abstract Background IL-10 knockout (KO) mice are protected from experimental autoimmune encephalomyelitis (EAE) with low-dose estrogen (E2) treatment similar to wild-type (WT) mice. Previous studies have demonstrated a decrease in tumor necrosis factor in all E2-treated groups, which led to the prot...

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Bibliographic Details
Main Authors: Hilary A. Seifert, Grant Gerstner, Gail Kent, Arthur A. Vandenbark, Halina Offner
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Neuroinflammation
Subjects:
Estrogen (E2)
PD-1 ligands
Regulatory B and T cells
IL-10
EAE inhibition
Online Access:http://link.springer.com/article/10.1186/s12974-019-1588-z

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http://link.springer.com/article/10.1186/s12974-019-1588-z

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