Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation

Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation

The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory T (Treg) cells remain unclear. Here, we show that selective deletion of CREB in T cells or Th17 cells impaired Th17 cell differentiation in vitro and in vivo, and led to resistance to autoi...

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Bibliographic Details
Main Authors: Xiaohu Wang, Lu Ni, Dehui Chang, Huiping Lu, Yu Jiang, Byung-Seok Kim, Aibo Wang, Xindong Liu, Bo Zhong, Xuexian Yang, Chen Dong
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:EBioMedicine
Subjects:
CREB
Th17 cells
Treg cells
Autoimmune diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417304048

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http://www.sciencedirect.com/science/article/pii/S2352396417304048

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