Conjugated β-Cyclodextrin Enhances the Affinity of Folic Acid towards FRα: Molecular Dynamics Study

Conjugated β-Cyclodextrin Enhances the Affinity of Folic Acid towards FRα: Molecular Dynamics Study

Drug targeting is a progressive area of research with folate receptor alpha (FRα) receiving significant attention as a biological marker in cancer drug delivery. The binding affinity of folic acid (FA) to the FRα active site provides a basis for recognition of FRα. In this study, FA was conjugated t...

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Bibliographic Details
Main Authors: Mohammad G. Al-Thiabat, Amirah Mohd Gazzali, Noratiqah Mohtar, Vikneswaran Murugaiyah, Ezatul Ezleen Kamarulzaman, Beow Keat Yap, Noorsaadah Abd Rahman, Rozana Othman, Habibah A. Wahab
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
targeted drug delivery system
folate receptor alpha
folic acid-conjugated cyclodextrins
molecular docking
molecular dynamics
radius of gyration (Rg)
Online Access:https://www.mdpi.com/1420-3049/26/17/5304

Internet

https://www.mdpi.com/1420-3049/26/17/5304

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