Proteasome Inhibition Contributed to the Cytotoxicity of Arenobufagin after Its Binding with Na, K-ATPase in Human Cervical Carcinoma HeLa Cells.

Although the possibility of developing cardiac steroids/cardiac glycosides as novel cancer therapeutic agents has been recognized, the mechanism of their anticancer activity is still not clear enough. Toad venom extract containing bufadienolides, which belong to cardiac steroids, has actually long b...

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Bibliographic Details
Main Authors: Qingxi Yue, Hong Zhen, Ming Huang, Xi Zheng, Lixing Feng, Baohong Jiang, Min Yang, Wanying Wu, Xuan Liu, Dean Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4948917?pdf=render