High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis

High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis

Summary: We investigated whether extracellular vesicles (EVs) produced under hyperglycemic conditions could communicate signaling to drive atherosclerosis. We did so by treating Apoe−/− mice with exosomes produced by bone marrow-derived macrophages (BMDM) exposed to high glucose (BMDM–HG-exo) or con...

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Bibliographic Details
Main Authors: Laura Bouchareychas, Phat Duong, Tuan Anh Phu, Eric Alsop, Bessie Meechoovet, Rebecca Reiman, Martin Ng, Ryo Yamamoto, Hiromitsu Nakauchi, Warren J. Gasper, Kendall Van Keuren-Jensen, Robert L. Raffai
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:iScience
Subjects:
Endocrine system physiology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221008154

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221008154

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