Identifying genomic targets for protein over-expression by “omics” analysis of Quiescent Escherichia coli cultures

Identifying genomic targets for protein over-expression by “omics” analysis of Quiescent Escherichia coli cultures

Abstract Background A cellular stress response is triggered upon induction of recombinant protein expression which feedback inhibits both growth as well as protein synthesis. In order to separate these two effects, it was decided to study “quiescent cultures” which continue to be metabolically activ...

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Bibliographic Details
Main Authors: Shubhashree Mahalik, Ashish Kumar Sharma, Priyanka Jain, Krishna Jyoti Mukherjee
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Microbial Cell Factories
Subjects:
E. coli
Quiescence
Cellular stress response
fis
Transcriptomic profiling
Asparaginase expression
Online Access:http://link.springer.com/article/10.1186/s12934-017-0744-3

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http://link.springer.com/article/10.1186/s12934-017-0744-3

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