Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans

Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans

The generation of high-affinity antibodies depends on somatic hypermutation (SHM). SHM is initiated by the activation-induced cytidine deaminase (AID), which generates uracil (U) lesions in the B-cell receptor (BCR) encoding genes. Error-prone processing of U lesions creates a typical spectrum of po...

Full description

Bibliographic Details
Main Authors: Hanna IJspeert, Pauline A. van Schouwenburg, Ingrid Pico-Knijnenburg, Jan Loeffen, Laurence Brugieres, Gertjan J. Driessen, Claudia Blattmann, Manon Suerink, Danuta Januszkiewicz-Lewandowska, Amedeo A. Azizi, Marcus G. Seidel, Heinz Jacobs, Mirjam van der Burg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
B cells
somatic hypermutation
DNA repair
mismatch repair (MMR)
base excision repair (BER)
immunoglobulin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01913/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01913/full

Similar Items