Transcription factors Sp1 and AP-2 mediate induction of acid sphingomyelinase during monocytic differentiation

Transcription factors Sp1 and AP-2 mediate induction of acid sphingomyelinase during monocytic differentiation

Cells from the human monocytic leukemia cell line THP-1 differentiate towards a macrophage-like phenotype when stimulated with phorbol 12-myristate-13-acetate (PMA), 1,25-dihydroxy-vitamin D3, and various other agents. We demonstrate here that the expression of the lysosomal enzyme acid sphingomyeli...

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Bibliographic Details
Main Authors: Thomas Langmann, Christa Buechler, Stefan Ries, Andreas Schaeffler, Charalampos Aslanidis, Marion Schuierer, Manfred Weiler, Konrad Sandhoff, Pieter J. de Jong, Gerd Schmitz
Format: Article
Language:English
Published: Elsevier 1999-05-01
Series:Journal of Lipid Research
Subjects:
acid sphingomyelinase
gene regulation
monocyte
macrophage
differentiation
ASM-promoter
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520321222

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http://www.sciencedirect.com/science/article/pii/S0022227520321222

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