Altered expression of MGMT in high-grade gliomas results from the combined effect of epigenetic and genetic aberrations.

Altered expression of MGMT in high-grade gliomas results from the combined effect of epigenetic and genetic aberrations.

MGMT downregulation in high-grade gliomas (HGG) has been mostly attributed to aberrant promoter methylation and is associated with increased sensitivity to alkylating agent-based chemotherapy. However, HGG harboring 10q deletions also benefit from treatment with alkylating agents. Because the MGMT g...

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Bibliographic Details
Main Authors: João Ramalho-Carvalho, Malini Pires, Susana Lisboa, Inês Graça, Patrícia Rocha, João Diogo Barros-Silva, Joana Savva-Bordalo, Joaquina Maurício, Mário Resende, Manuel R Teixeira, Mrinalini Honavar, Rui Henrique, Carmen Jerónimo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3594314?pdf=render

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http://europepmc.org/articles/PMC3594314?pdf=render

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