Altered Synaptic and Extrasynaptic NMDA Receptor Properties in Substantia Nigra Dopaminergic Neurons From Mice Lacking the GluN2D Subunit

Altered Synaptic and Extrasynaptic NMDA Receptor Properties in Substantia Nigra Dopaminergic Neurons From Mice Lacking the GluN2D Subunit

N-methyl-D-aspartate receptors (NMDARs) are ubiquitously expressed in the mammalian brain and are essential for neuronal development, survival and plasticity. GluN2 subunit composition has a profound effect on the properties of NMDARs. In substantia nigra dopaminergic (SNc-DA) neurons, pharmacologic...

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Bibliographic Details
Main Authors: Paul G. Morris, Masayoshi Mishina, Susan Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
NMDA receptor
GluN2D subunit
GluN2B subunit
substantia nigra
dopamine neuron
NMDAR-EPSC
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00354/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00354/full

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